Anti-Müllerian hormone levels in recurrent embryonic miscarriage patients.
This prospective cohort study measured anti-Müllerian hormone (AMH) levels in recurrent miscarriage (RM) patients, compared them to a normal population, and assessed the pregnancy outcomes. The RM patients demonstrated AMH levels that were significantly lower than the normal population, both in women aged ≤35 years, and those aged >35 years.
Dr. Denise Furness's research while affiliated with the University of Adelaide.
Some studies have suggested that vitamin D deficiency is associated with an increased risk of first trimester miscarriages, others have suggested that it is associated with an increased risk of hyperinsulinism/insulin resistance and the development of gestational diabetes.
Association between vitamin D status and hyperinsulinism.
Some studies have suggested that vitamin D deficiency is associated with an increased risk of first trimester miscarriages, others have suggested that it is associated with an increased risk of hyperinsulinism/insulin resistance and the development of gestational diabetes. Hyperinsulinism is also thought to increase miscarriages. We investigated the association between vitamin D levels and hyperinsulinism in a cohort of recurrent miscarriage patients.
In healthy pregnancy reactive oxygen species and antioxidants remain in balance and DNA damage is repaired effectively. However, pregnancy is an inflammatory state exhibiting increased susceptibility to oxidative stress such that this balance can be easily disrupted. Increased DNA damage has been shown to be involved in many pathological states including pregnancy complications.
The primary aim of this study was to determine if maternal folate, vitamin B12, vitamin B6 and homocysteine concentrations at 18–20 weeks gestation are associated with subsequent adverse pregnancy outcomes, including pre-eclampsia and intrauterine growth restriction (IUGR). The secondary aim was to investigate maternal B vitamin concentrations with DNA damage markers in maternal lymphocytes. A prospective observational study was conducted at the Women's and Children's Hospital, Adelaide, South Australia.
This was a prospective cohort study consisting of 50 women at low risk and 93 women at high risk for having a pregnancy complication develop. Maternal and fetal DNA samples were genotyped for methionine synthase (MTR) A2756G, methionine synthase reductase (MTRR) A66G and methylenetetrahydrofolate dehydrogenase (MTHFD1) G1958A. A chi squared or chi(2) analysis was used to compare genotypes and pregnancy outcome, 1-way analysis of variance and linear regression were used to compare genotype with continuous variables.
This was a prospective cohort study conducted at Commonwealth Scientific and Industrial Research Organisation Food and Nutritional Sciences and at the Women’s and Children’s Hospital (WCH), Adelaide, South Australia, Australia. The study was approved by the Human Experimentation and Research Ethics Committees of both institutions. Pregnant volunteers were enrolled in early pregnancy (before 20 weeks gestation), after obtaining informed consent.
To determine if maternal circulating red blood cell (RBC) folate concentration in early pregnancy is associated with late gestation pregnancy complications including small for gestational age (SGA) infants, preeclampsia and preterm birth (PTB) in a socioeconomically disadvantaged population.
Women who suffer recurrent miscarriage are a heterogeneous group. Known causes include genetic and endocrine abnormalities, anti-phospholipid syndrome and autoimmune disease. Congenital uterine abnormalities (CUAs) such as bicornuate, unicornuate, septate and arcuate uterine abnormalities are known to negatively impact on pregnancy rates, and to increase the miscarriage rates of genetically normal pregnancies.
The SCOPE study arises from the knowledge that there are a number of potential clinical and molecular markers (certain proteins, fats and small molecules in the blood) for these complications. None of these candidate markers areuseful as individual predictive tests, but combinations of markers are likely to result in clinically useful screening tests.
Genome Damage and Folate Nutrigenomics in Uteroplacental insufficiency. Denise Lyndal Fleur Furness BSc (Honours). A Thesis submitted for the Degree of Doctor of Philosophy. The university of Adelaide, School of Health Sciences, Discipline of Obstetrics and Gynaecology and CSIRO Human Nutrition, Genome Health and Nutrigenomics Laboratory.